The Best Supplements to Take With Ozempic, Mounjaro and Wegovy
GLP-1 medications like Ozempic, Mounjaro, and Wegovy have revolutionised weight management and are approved in the UK for treating obesity. But because these medications work by mimicking the GLP-1 hormone and reducing appetite, they can compromise your nutrient intake.
Combining supplements with GLP-1 medications requires a balancing act, as some vitamins and minerals can increase side effects.
In this post, we'll reveal the best supplements to take alongside Wegovy, Mounjaro, and Ozempic treatment.
What are GLP-1 Medications?
GLP-1 medications like Mounjaro, Wegovy and Ozempic are proven to help users lose weight by mimicking the natural hormone your body releases after eating.
By slowing digestion, reducing blood sugar, and decreasing appetite, these medications can help users reach a healthy body weight.
However, they're only suitable for individuals with a BMI of 30 and over, or 27 with a co-morbid condition. Weight-loss injections are highly effective, with users reducing their body weight by 15% to 22% with long-term use (PMC).
However, because of how they work, these medications can also lead to vitamin and mineral deficiencies.
The New WLP-1 Medications
Because GLP-1 injections can result in significant weight loss, they're only suitable for people classified as obese or overweight with a related condition. A new WLP-1 medication is quickly gaining recognition as a potential OTC alternative.
Produced by The Absorption Company, WLP-1™ claims to support natural GLP-1 activity, which enhances thermogenesis and reduces appetite.
Made with CQR300® (a Cissus quadrangularis extract), African mango extract, and capsaicin, the medication is relatively new but could be an alternative when traditional GLP-1s are inaccessible due to price or affordability.
However, another popular weight management supplement to try is Glucomannan, which is a form of dietary fibre. It works by creating a thick gel in the stomach, which reduces your appetite and can support weight loss.
Glucomannan is also beneficial for gut health, as it can reduce or prevent constipation.
The Best Dietary Supplements to Take with GLP-1 Medications
|
Supplement |
Why It Can Help GLP-1 Users |
Key Benefit |
|---|---|---|
|
Protein |
Helps compensate for lower protein intake due to fewer calories |
Maintaining muscle mass and preventing muscle loss |
|
Fibre |
Supports digestion when gastric emptying slows due to dietary restrictions |
Helps prevent constipation |
|
Vitamin D |
Addresses potential gaps from reduced food intake |
Supports bones and muscles |
|
Magnesium |
Helps maintain adequate intake during calorie restriction |
Supports muscles and energy |
|
Multivitamin |
Provides a broad range of vitamins and minerals |
Helps fill nutritional gaps |
|
Collagen |
Can reduce the risks of hair loss, sagging skin, and brittle nails |
Supports the hair, skin, and nails during rapid weight loss |
1: Protein Supplements

Weight loss from GLP-1 medications isn't necessarily limited to your body fat. Unfortunately, it can also lead to muscle and bone loss, which means you'll need to work harder to preserve muscle mass.
Strength training exercises can help, but increasing your protein intake is beneficial. Consuming high-protein foods can be challenging, especially when your appetite is naturally lower, which is why many people turn to protein and meal replacement shakes.
Our meal replacements have 15 grams of protein and are only 222 calories per serving.
2: Fibre

Studies show that 30% of GLP-1 users will experience constipation due to delayed gastric emptying (NIH). The side effects are most common when starting the medication or increasing your dose, but fibre can support your digestive system.
Consuming more whole foods, vegetables, fruit, and grains can reduce the risks of constipation, but Fibre Gummies can fill small nutritional gaps or offer additional support alongside a balanced diet.
The recommended daily intake of fibre is 30 grams for adults, and combining whole foods with supplements can help you reach this.
3: Vitamin D

The body doesn't produce Vitamin D naturally. Instead, it relies on natural sunlight and foods that contain it. As one of the most essential vitamins, low levels can cause a range of symptoms, including weaker muscles, reduced bone health, and lethargy.
Studies show that Vitamin D deficiency occurs in over 13% of GLP-1 users, due to nutritional gaps from reduced dietary intake (Harvard Health).
The NHS advises everyone in the UK to take Vitamin D supplements during the autumn and winter due to reduced sunlight, but they're particularly vital if you're using weight loss medications.
4: Magnesium

Nutrient deficiencies are common when using GLP-1s because they decrease your food intake and slow gastric emptying, which impacts nutrient absorption. Signs of low magnesium include fatigue, muscle cramps, and worse constipation.
Taking a Magnesium Supplement can be beneficial, but avoid magnesium oxide, as it can increase the risk of digestive symptoms.
5: Multivitamins
Choosing the right essential vitamin and mineral supplements can be challenging, but a daily Multivitamin can fill any nutrient gaps while also supporting your weight loss journey. The key is to find the right option for your needs.
For example, at Sealions, we offer specialist formulations, including Men's and Women's Multivitamin Gummies, designed for unique dietary needs.
6: Collagen Supplements
Because GLP-1 medicines can cause rapid weight loss and affect the absorption of fat-soluble vitamins, they can result in hair loss and reduced skin elasticity. Using collagen powder or taking Hair Skin & Nails Gummies that support collagen production can help prevent this.
Supplements Shouldn't Replace a Balanced Diet
While supplements can be beneficial when using GLP-1 medications, they shouldn't replace a healthy diet that includes protein, fibre, whole grains, Vitamin C-rich foods, and other nutrient-dense foods.
However, if you're experiencing side effects like abdominal pain or reduced appetite, essential vitamins and minerals can help.
It's always a good idea to speak to a healthcare professional before using supplements, as they may recommend blood tests to determine where your deficiencies are.
Most importantly, avoid high doses of caffeine and fat burners, as they can cause jitters and increase heart rate.
Access Affordable Essential Vitamins and Minerals at Sealions
When using weight loss injections, certain vitamins and minerals can reduce your side effects and fill any nutritional gaps.
Sealions offers a range of affordable supplements made with the highest-quality ingredients. If you need advice on which supplements to take, we're here to help. Please get in touch with us today.